While debating the existence of God with a theist for some time now and having become mired down in the same ontological, teleological and cosmological arguments, I developed a new argument against the existence of God, at least I am unaware of one like it:
God exists beyond our realm.
We cannot know of the existence of anything beyond our own realm.
Therefore we know God does not exist.
To support the first premise it is critical that I clarify "our realm" (OR) and why God exists there. OR is that of the natural universe and the laws that govern it and God is a supernatural being, and not just because religion states this but because God would have to be in order to accomplish what he supposedly has done, can do and will do. The supernatural is exactly that, a realm beyond ours where the natural laws of the universe do not govern.
Any realm that could possibly exist that is governed by different laws would not make it possible for us to exist in it, therefore even if something could possibly exist beyond OR and if it could attempt to interact, manipulate, intervene or effect anything in OR we would be totally oblivious. Either by our laws confining the effect to a zero or by completely unraveling our laws and universe the moment of such an effect, no matter how small. Even thoughts, and this is the important part, of anything beyond OR are impossible for us because not only do our thoughts originate from OR but their existence depends on it and because any realm beyond OR would contain actions based on different laws that would make it impossible to conceive thoughts of that realm. Our thoughts are the result of complex functions of a complex brain that is unable to produce a truly irrational processes such as matter moving in a direction absolutely opposite to the direction it is moving. The mind is incapable of producing a clear thought based on incorrect data input.